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AstraZeneca has licensed ECC5004, an investigational oral once-daily glucagon-like peptide 1 receptor agonist (GLP-1RA), from Eccogene for the treatment of obesity, type 2 diabetes, and other cardiometabolic conditions

Engages GLP-1 receptors in the hypothalamus and hindbrain to reduce hunger, increase satiety, and lower overall energy intake the primary driver of the weight reduction observed in the STEP trial program

5 , 6, 11 13 In males, the head, neck, and trunk are particularly affected whereas in females the upper and lower limbs are more often involved

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Patients were blinded to intervention during the period